Cell-free fetal nucleic acids in amniotic fluid
L Hui, DW Bianchi
Human Reproduction Update | OXFORD UNIV PRESS | Published : 2011
BACKGROUND: Research into cell-free fetal (cff) nucleic acids has primarily focused on maternal plasma; however, cff DNA and RNA are also detectable in other body fluids such as amniotic fluid (AF). In AF, cff DNA is present in much greater concentrations than in maternal plasma and represents a pure fetal sample uncontaminated by maternal- and trophoblast-derived nucleic acids. The aim of this review was to summarize the current knowledge on cff nucleic acids in AF and to outline future research directions. METHODS: MEDLINE and PREMEDLINE were searched up to August 2010 for original investigations of cell-free RNA or DNA in AF. Sixteen studies were included in the review. RESULTS: AF cff DN..View full abstract
Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
L.H. is the recipient of the Albert S. McKern scholarship from the University of Sydney and the Fotheringham Fellowship from the Royal Australian and New Zealand College of Obstetricians and Gynaecologists. D.W.B. receives grant support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 42053-07).