Journal article
Paracingulate sulcus morphology is associated with hallucinations in the human brain
JR Garrison, C Fernyhough, S McCarthy-Jones, M Haggard, V Carr, U Schall, R Scott, A Jablensky, B Mowry, P Michie, S Catts, F Henskens, C Pantelis, C Loughland, JS Simons
Nature Communications | NATURE PUBLISHING GROUP | Published : 2015
DOI: 10.1038/ncomms9956
Abstract
Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1cm reduction in sulcal length increasing the likel..
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Awarded by Australian Research Council
Funding Acknowledgements
We thank Trevor Robbins for comments and advice. J.R.G. was supported by a University of Cambridge Behavioural and Clinical Neuroscience Institute studentship, funded by a joint award from the UK Medical Research Council and the Wellcome Trust. C.F. was supported by a Wellcome Trust Strategic Award. S.M.-J. was supported by an Australian Research Council Discovery Early Career Researcher Award. J.S.S. was supported by a James S. McDonnell Foundation Scholar award. Data were provided by the Australian Schizophrenia Research Bank (ASRB; CIs, Carr V, Schall U, Scott R, Jablensky A, Mowry B, Michie P, Catts S, Henskens F, Pantelis C, Loughland C), which is supported by the National Health and Medical Research Council of Australia, the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute.