Journal article

Correlation of Ga-68 Ventilation-Perfusion PET/CT with Pulmonary Function Test Indices for Assessing Lung Function

Pierre-Yves Le Roux, Shankar Siva, Daniel P Steinfort, Jason Callahan, Peter Eu, Lou B Irving, Rodney J Hicks, Michael S Hofman

Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2015

Abstract

UNLABELLED: Pulmonary function tests (PFTs) are routinely used to assess lung function, but they do not provide information about regional pulmonary dysfunction. We aimed to assess correlation of quantitative ventilation-perfusion (V/Q) PET/CT with PFT indices. METHODS: Thirty patients underwent V/Q PET/CT and PFT. Respiration-gated images were acquired after inhalation of (68)Ga-carbon nanoparticles and administration of (68)Ga-macroaggregated albumin. Functional volumes were calculated by dividing the volume of normal ventilated and perfused (%NVQ), unmatched and matched defects by the total lung volume. These functional volumes were correlated with forced expiratory volume in 1 s (FEV1), ..

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Grants

Awarded by Cancer Australia Priority-drive Collaborative Cancer Research Scheme Grant


Awarded by National Health and Medical Research Council


Funding Acknowledgements

The costs of publication of this article were defrayed in part by the payment of page charges. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 USC 1734. This research has been supported by Cancer Australia Priority-drive Collaborative Cancer Research Scheme Grant 2013, APP1060919. Dr. Shankar Siva has received National Health and Medical Research Council scholarship funding for this research, APP1038399. Dr. Pierre-Yves Le Roux has received funding from the France-Australia Science Innovation Collaboration (FASIC) program.