Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency
Lisandra L Martin, Jessica K Holien, Dario Mizrachi, C Jo Corbin, Alan J Conley, Michael W Parker, Raymond J Rodgers
The Journal of Steroid Biochemistry and Molecular Biology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
This research was supported by the National Health and Medical Research Council of Australia (NHMRC) and the Australian Research Council. We thank Dr. Slavica Praporski, Miss Daphne Y.S. Wong and Dr. Katja Hummitzsch for their assistance and Assoc. Professor Ashley Buckle for discussions on the molecular dynamics and Dr. Alexandr Simonov for thoughtful contributions. This work was also supported by a capital grant from the Australian Cancer Research Foundation and infrastructure funding from the Victorian Government (Australia) Operational Infrastructure Support Scheme to St. Vincent's Institute of Medical Research. M.W.P. is an NHMRC Research Fellow and J.K.H. is a joint Cure Cancer/Leukaemia Foundation Post-Doctoral Fellow.