Journal article
Placental Histopathological Changes Associated with Plasmodium vivax Infection during Pregnancy
RM Souza, R Ataíde, JG Dombrowski, V Ippólito, EH Aitken, SN Valle, JM Álvarez, S Epiphânio, CRF Marinho
Plos Neglected Tropical Diseases | Published : 2013
Abstract
Histological evidence of Plasmodium in the placenta is indicative of placental malaria, a condition associated with severe outcomes for mother and child. Histological lesions found in placentas from Plasmodium-exposed women include syncytial knotting, syncytial rupture, thickening of the placental barrier, necrosis of villous tissue and intervillositis. These histological changes have been associated with P. falciparum infections, but little is known about the contribution of P. vivax to such changes. We conducted a cross-sectional study with pregnant women at delivery and assigned them to three groups according to their Plasmodium exposure during pregnancy: no Plasmodium exposure (n = 41), ..
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Awarded by Fundacao de Apoio a Pesquisa do Estado de Sao Paulo -FAPESP
Awarded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES
Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
Awarded by CNPq
Awarded by FAPESP
Awarded by SE (Jovem Pesquisador)
Awarded by CRFM (Jovem Pesquisador)
Funding Acknowledgements
Financial support was provided by Fundacao de Apoio a Pesquisa do Estado de Sao Paulo -FAPESP (Grant n degrees 2009/53.889-0), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES (Grant n degrees AUX-PE-PNPD 2751/2010 and 258/2010) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq (Grant n degrees 475771/2009-5). RMS is supported by Universidade Federal do Acre, CAPES and CNPq (scholarship 141946/2012-1), RA is supported by FAPESP (fellowship 2011/20921-8), JGD is supported by CNPq (scholarship 141684/2012-7), VI was supported by CNPq (scholarship PIBIC/6414681), EHA is supported by FAPESP (fellowship 2011/19525-0), SE (Jovem Pesquisador, Grant n degrees 2009/53256-7), CRFM (Jovem Pesquisador, Grant n degrees 2009/53.889-0). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.