The complement of family M1 aminopeptidases of Haemonchus contortus - Biotechnological implications
Namitha Mohandas, Neil D Young, Abdul Jabbar, Pasi K Korhonen, Anson V Koehler, Ross S Hall, Min Hu, Andreas Hofmann, Robin B Gasser
BIOTECHNOLOGY ADVANCES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Although substantial research has been focused on the 'hidden antigen' H11 of Haemonchus contortus as a vaccine against haemonchosis in small ruminants, little is know about this and related aminopeptidases. In the present article, we reviewed genomic and transcriptomic data sets to define, for the first time, the complement of aminopeptidases (designated Hc-AP-1 to Hc-AP-13) of the family M1 with homologues in Caenorhabditis elegans, characterised by zinc-binding (HEXXH) and exo-peptidase (GAMEN) motifs. The three previously published H11 isoforms (accession nos. X94187, FJ481146 and AJ249941) had most sequence similarity to Hc-AP-2 and Hc-AP-8, whereas unpublished isoforms (accession nos. ..View full abstract
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Awarded by Victorian Life Sciences Computation Initiative (VLSCI) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government
The research funding from the Australian Research Council (ARC) and National Health and Medical Research Council of Australia (NHMRC) is gratefully acknowledged (R.B.G.). This project was also supported by a Victorian Life Sciences Computation Initiative (VLSCI) (grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government (R.B.G.). N.D.Y. holds an NHMRC Early Career Research Fellowship. P.K.K. is the recipient of a scholarship (STRAPA) from the University of Melbourne.