Population pharmacokinetics of tenofovir in HIV/HBV co-infected patients

Abstract

Objective: Tenofovir is an efficacious drug with a long half-life and high activity against both HIV and HBV. However, the pharmacokinetics of tenofovir have not been studied in HIV/HBV co-infected patients. Data from HIV mono-infected patients may not be transferable to HIV/HBV co-infected population because the nature and consequences of the co-infection are different. This study developed a population pharmacokinetic model of tenofovir in patients with HIV/HBV co-infection and identified pathophysiologic factors that affect the pharmacokinetics of the drug. Methods: Sparse and intensive blood samples were collected from patients with HIV/HVB coinfection. The population pharmacokinetic mod..