The role of naive T-cells in HIV-1 pathogenesis: An emerging key player
Gabriela Khoury, Reena Rajasuriar, Paul U Cameron, Sharon R Lewin
Clinical Immunology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2011
Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.
G.K is a recipient of the National Health and Medical Research Council (NHMRC) biomedical postgraduate scholarship.S.R.L is funded by the NHMRC and Alfred Foundation and is an NHMRC Practitioner FellowP.U.C and S.R.L were funded by an NHMRC program grant for this work.R.R is a recipient of the King Scholarship from the Malaysian government.