Journal article
Plasma levels of soluble CD14 independently predict mortality in HIV infection
NG Sandler, H Wand, A Roque, M Law, MC Nason, DE Nixon, C Pedersen, K Ruxrungtham, SR Lewin, S Emery, JD Neaton, JM Brenchley, SG Deeks, I Sereti, DC Douek
Journal of Infectious Diseases | Published : 2011
Abstract
Background. Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to systemic immune activation, which is an independent predictor of HIV disease progression. The association of microbial translocation with clinical outcome remains unknown. Methods. This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibo..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported in part by the intramural program of the National Institute of Allergy and Infectious Disease, National Institutes of Health and NIH grant AI-76174. K. R. is partially supported by the Research Team Strengthening Grant, the National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand.