Journal article
Factors associated with elevated ALT in an international HIV/HBV Co-Infected cohort on long-term HAART
J Audsley, EC Seaberg, J Sasadeusz, GV Matthews, A Avihingsanon, K Ruxrungtham, K Fairley, R Finlayson, HS Hwang, M Littlejohn, S Locarnini, GJ Dore, CL Thio, SR Lewin
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Background: Previous studies have demonstrated that hepatitis B virus (HBV) infection increases the risk for ALT elevations in HIV-HBV co-infected patients during the first year of HAART; however, there is limited data on the prevalence of ALT elevations with prolonged HAART in this patient group. Methods/Principal findings: To identify factors associated with ALT elevations in an HIV-HBV co-infected cohort receiving prolonged HAART, data from 143 co-infected patients on HAART enrolled in an international HIV-HBV co-infected cohort where ALT measurements were obtained every 6 months was analysed. A person-visit analysis was used to determine frequency of ALT elevation (≥2.5×ULN) at each visi..
View full abstractRelated Projects (2)
Grants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The authors acknowledge funding from the National Institutes of Health RO1 A1060449. Some of the data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centres (Principal Investigators) at The Johns Hopkins Bloomberg School of Public Health (Joseph B. Margolick, Lisa P. Jacobson), Howard Brown Health Center, Feinberg School of Medicine, Northwestern University, and Cook County Bureau of Health Services (John P. Phair, Steven M. Wolinsky), University of California, Los Angeles (Roger Detels), and University of Pittsburgh (Charles R. Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute, grants UO1-AI-35042, UL1-RR025005 (GCRC), UO1-AI-35043, UO1-AI-35039, UO1-AI-35040, and UO1-AI-35041. JA is a Nation Health and Medical Research Council (NHMRC) Clinical Research Training Fellow and SRL is an NHMRC Practitioner Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.