Splenectomy Associated Changes in IgM Memory B Cells in an Adult Spleen Registry Cohort
Paul U Cameron, Penelope Jones, Malgorzata Gorniak, Kate Dunster, Eldho Paul, Sharon Lewin, Ian Woolley, Denis Spelman
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2011
Asplenic patients have a lifelong risk of overwhelming post-splenectomy infection and have been reported to have low numbers of peripheral blood IgM memory B cells. The clinical value of quantitation of memory B cells as an indicator of splenic abnormality or risk of infection has been unclear. To assess changes in B cell sub-populations after splenectomy we studied patients recruited to a spleen registry (n = 591). A subset of 209 adult asplenic or hyposplenic subjects, and normal controls (n = 140) were tested for IgM memory B cells. We also determined a) changes in IgM memory B cells with time after splenectomy using the cross-sectional data from patients on the registry and b) the kineti..View full abstract
This work was supported by a grant from the Flack foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.