Hepatitis C prevalence among HIV-infected patients in Guinea-Bissau: a descriptive cross-sectional study
Bo Langhoff Honge, Sanne Jespersen, Candida Medina, David da Silva Te, Zacarias Jose da Silva, Sharon R Lewin, Lars Ostergaard, Alex Lund Laursen, Henrik Krarup, Christian Erikstrup, Christian Wejse
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | ELSEVIER SCI LTD | Published : 2014
OBJECTIVES: To estimate the prevalence and determine the clinical presentation of risk factors of hepatitis C virus (HCV) among HIV-infected patients in Bissau, Guinea-Bissau. METHODS: In this cross-sectional study, we included individuals who had a routine blood analysis performed during the period April 28 to September 30, 2011. Patient samples were tested for HCV antibodies (anti-HCV) with a chemiluminescence test (Architect, Abbott, USA) and INNO-LIA HCV Score (Innogenetics, Belgium). HCV viral load and genotype were analyzed using an in-house real-time PCR method. RESULTS: In total, 576 patients were included (417 HIV-1, 104 HIV-2, and 55 HIV-1/2). Ten (1.7%) patients were anti-HCV-posi..View full abstract
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Awarded by Lundbeck Foundation
The study was supported by the Bandim Health Project, 'Overl'ge Johan Boserup og Lise Boserups Legat', 'Aage og Johanne Louis-Hansens Fond', 'Jacob og Olga Madsens Fond', and 'Aase og Ejnar Danielsens Fond'. The Global Fund to Fight AIDS, TB and Malaria (Global Fund) supported the data collection during 2009-2013 through the 'Secretariado National de Luta contra o Sida' in Guinea-Bissau. The Ministry of Foreign Affairs of Denmark (DANIDA) provided a travel grant for BLH; Aarhus University, Denmark supported a 1-year scholarship for BLH. Abbott provided serology reagents. WAPHIR and IeDEA supported data collection in Bissau. The sponsors had no influence on the study design, data collection and analysis, interpretation of the data, or drafting of the manuscript.