Finding a cure for HIV: will it ever be achievable?
Sharon R Lewin, Vanessa A Evans, Julian H Elliott, Bruno Spire, Nicolas Chomont
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY | JOHN WILEY & SONS LTD | Published : 2011
Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity. However, HIV still cannot be cured. With the absence of an effective prophylactic or therapeutic vaccine, increasing numbers of infected people, emerging new toxicities secondary to cART and the need for life-long treatment, there is now a real urgency to find a cure for HIV.There are currently multiple barriers to curing HIV. The most significant barrier is the establishment of a latent or "silent" infection in resting CD4+ T cells. In latent HIV infection, the virus is able to integrate into the host cell genome, but does not proceed to active replication. As a consequence, antivi..View full abstract