Early Events of HIV-1 Infection: Can Signaling be the Next Therapeutic Target?
Kate L Jones, Redmond P Smyth, Cndida F Pereira, Paul U Cameron, Sharon R Lewin, Anthony Jaworowski, Johnson Mak
Journal of Neuroimmune Pharmacology | SPRINGER | Published : 2011
Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel ta..View full abstract
We acknowledge the financial support from the National Health and Medical Research Council (NHMRC) of Australia (CFP, PUC, SRL, AJ, JM), the Australian Research Council (JM), Australian Centre for HIV and Hepatitis Viruses (SRL, KLJ, JM), National Institute of Health (SRL, JM), the Portuguese Foundation for Science and Technology (CFP), the Alfred Foundation (SRL) and the Northcote King's College Training Fellowship (RPS). SRL is an NHMRC Practitioner Fellow. JM is a recipient of the Pfizer Foundation Fellowship and ARC Future Fellowship.