Journal article

Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection

LA Chakrabarti, SR Lewin, LQ Zhang, A Gettie, A Luckay, LN Martin, E Skulsky, DD Ho, C Cheng-Mayer, PA Marx

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2000


Sooty mangabeys naturally infected with simian immunodeficiency virus (SIV) remain healthy though they harbor viral loads comparable to those in rhesus macaques that progress to AIDS. To assess the immunologic basis of disease resistance in mangabeys, we compared the effect of SIV infection on T-cell regeneration in both monkey species. Measurement of the proliferation marker Ki-67 by flow cytometry showed that mangabeys harbored proliferating T cells at a level of 3 to 4% in peripheral blood irrespective of their infection status. In contrast, rhesus macaques demonstrated a naturally high fraction of proliferating T cells (7%) that increased two- to threefold following SIV infection. Ki-67(..

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University of Melbourne Researchers