The anti-HIV activity of entecavir: A multicentre evaluation of lamivudine-experienced and lamivudine-naive patients

Abstract

BACKGROUND: Entecavir, an antiviral with potent anti-hepatitis B virus activity, was recently shown to have anti-HIV activity in three patients and the ability to select for the lamivudine-resistant HIV polymerase mutation M184V in a patient with prior antiretroviral therapy. OBJECTIVES: To further characterize entecavir's anti-HIV activity and identify risk factors for selection of the M184V. DESIGN: Retrospective cohort study. METHODS: We evaluated the virological characteristics of HIV and hepatitis B virus in 17 HIV-hepatitis B virus coinfected patients (10 antiretroviral therapy-naive and seven antiretroviral therapy-experienced) prior to and during entecavir monotherapy. Descriptive st..