Efficacy of tenofovir disoproxil fumarate/emtricitabine compared with emtricitabine alone in antiretroviral-naive HIV-HBV coinfection in Thailand
Anchalee Ayihingsanon, Sharon R Lewin, Stephen Kerr, Judy J Chang, Komolmit Piyawat, Nounpen Napissanant, Gall V Matthews, Gregory J Dore, Scott Bowden, Joep Lange, Kiat Ruxrungtham
Antiviral Therapy | INT MEDICAL PRESS LTD | Published : 2010
BACKGROUND: Therapy for chronic hepatitis B with tenofovir disoproxil fumarate (TDF) and lamivudine (3TC) or emtricitabine (FTC) is currently recommended for HIV-HBV coinfection. However, there is limited randomized data on the efficacy of combined therapy with TDF and FTC, especially in antiretroviral (ARV)-naive patients. METHODS: This was a prospective randomized clinical trial comparing the efficacy of HBV monotherapy with FTC versus TDF/FTC combination therapy in ARV-naive HIV-HBV coinfection. HIV-HBV-coinfected patients initiating ARV were randomized to either FTC/zidovudine/efavirenz (EFV; n=6) or TDF/FTC/EFV (n=10). The primary end point was the time-weighted area under the curve (TW..View full abstract
This study was presented orally at the 12th European AIDS Conference (11-14 November 2009, Cologne, Germany; abstract PS2). The clinical trial registration number for this study is 00476463. The study was funded by Gilead Sciences, but the company had no role on the analysis and reporting of these results.KR has received research grants/funding, honoraria and lecture sponsorships from, or is a consultant or advisor to, Abbott Laboratories, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline and F Hoffmann-La Roche. JL has received consultancy fees and honoraria from GlaxoSmithKline, Boehringer-Ingelheim, Bristol-Myers Squibb, F Hoffmann-La Roche, Merck Sharp & Dohme, Schering-Plough, Bayer, Shire Pharmaceuticals, Agouron/Pfizer and Virco/Tibotec. SRL has received research and travel grants from Gilead Sciences, Pfizer, Bristol-Myers Squibb, Merck, Sharp & Dohme and GlaxoSmithKline. All other authors declare no competing interests.