Journal article

Immune Restoration Diseases Reflect Diverse Immunopathological Mechanisms

Patricia Price, David M Murdoch, Upasna Agarwal, Sharon R Lewin, Julian H Elliott, Martyn A French

Clinical Microbiology Reviews | AMER SOC MICROBIOLOGY | Published : 2009

Abstract

Up to one in four patients infected with human immunodeficiency virus type 1 and given antiretroviral therapy (ART) experiences inflammatory or cellular proliferative disease associated with a preexisting opportunistic infection, which may be subclinical. These immune restoration diseases (IRD) appear to result from the restoration of immunocompetence. IRD associated with intracellular pathogens are characterized by cellular immune responses and/or granulomatous inflammation. Mycobacterial and cryptococcal IRD are attributed to a pathological overproduction of Th1 cytokines. Clinicopathological characteristics of IRD associated with viral infections suggest different pathogenic mechanisms. F..

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University of Melbourne Researchers