Journal article

No Increase in Hepatitis B Virus (HBV)-Specific CD8( ) T Cells in Patients with HIV-1-HBV Coinfections following HBV-Active Highly Active Antiretroviral Therapy

Megan Crane, Sunee Sirivichayakul, J Judy Chang, Anchalee Avihingsanon, Sasiwimol Ubolyam, Supranee Buranapraditkun, Pattarawat Thantiworasit, Fiona Wightman, Stephen Locarnini, Gail Matthews, Gregory J Dore, Kiat Ruxrungtham, Sharon R Lewin

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2010


Following treatment of hepatitis B virus (HBV) monoinfection, HBV-specific T-cell responses increase significantly; however, little is known about the recovery of HBV-specific T-cell responses following HBV-active highly active antiretroviral therapy (HAART) in HIV-HBV coinfected patients. HIV-HBV coinfected patients who were treatment naïve and initiating HBV-active HAART were recruited as part of a prospective cohort study in Thailand and followed for 48 weeks (n = 24). Production of gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in both HBV- and HIV-specific CD8(+) T cells was quantified using intracellular cytokine staining on whole blood. Following HBV-active H..

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Awarded by National Institutes of Health

Awarded by National Health and Medicine Research Council


Funding Acknowledgements

This study was funded by the National Institutes of Health (NIH R21 AI055379-01) and Gilead Sciences. S. R. L. is supported by the Alfred Foundation and is a National Health and Medicine Research Council Practitioner Fellow (grant 251651).K. R. has recently received research grants/funding, honoraria, or has been a consultant or advisor to, or received lecture sponsorships from Abbott, Boehringer-Ingelheim, Bristol-Myers-Squibb, Gilead, GlaxoSmithKline, Hoffmann-LaRoche, Janssen-Cilag, Merck Sharpe & Dolme, Tibotec and Virco. S. R. L. has received research grants/funding from Roche, Bristol-Myers-Squibb, Gilead, and Pfizer.We thank Tim Spelman for his expert statistical advice, Pip Marks for study coordination, and the patients for their participation in this study.