Ten years of highly active antiretroviral therapy for HIV infection

Abstract

• Over the past 10 years, the management of HIV infection has been transformed by an increased number of effective antiretrovirals (ARVs), with more convenient dosing and improved tolerability. • Optimal management of HIV infection includes at least three effective ARVs; from at least two different drug classes. • Current strategies and drugs can effectively control HIV and significantly reduce morbidity and mortality. However, no cure is yet possible. • Appropriate use of ARVs leads to suppression of virological replication (to below the limit of detection using commercial assays to measure HIV in plasma) and an increase in CD4+ T cells with few adverse effects. • Greater than 95% adherence..