Journal article

Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys

LA Chakrabarti, SR Lewin, LQ Zhang, A Gettie, A Luckay, LN Martin, E Skulsky, DD Ho, C Cheng-Mayer, PA Marx

Journal of Medical Primatology | MUNKSGAARD INT PUBL LTD | Published : 2000


Sooty mangabeys (Cercocebus atys) showed age-dependent changes in T cell regeneration. Younger animals had a high percentage of CD4+ CD45RA + T cells and a high concentration of T cell receptor excisional circles (TRECs) in peripheral blood, which indicated active thymopoiesis. In contrast, older animals had an increased T cell turnover, which suggested that most T cell production occurred in the periphery. In addition, the number of peripheral CD4+ T cells naturally decreased with age. Non-pathogenic SIVsm infection did not significantly change the T cell proliferation rate or the TREC concentration, though it did cause a moderate loss of peripheral CD4 + T cells. The viral load correlated ..

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University of Melbourne Researchers