Journal article

Effectiveness of less than three doses of quadrivalent human papillomavirus vaccine against cervical intraepithelial neoplasia when administered using a standard dose spacing schedule: Observational cohort of young women in Australia

Julia ML Brotherton, Michael Malloy, Alison C Budd, Marion Saville, Kelly T Drennan, Dorota M Gertig

Papillomavirus Research | ELSEVIER SCIENCE BV | Published : 2015

Abstract

Background: Optimised two-dose human papillomavirus (HPV) vaccine schedules are now endorsed for young adolescents by the World Health Organization. Limited data are available about effectiveness of <3 doses using a standard dose schedule. Methods: Deterministic data linkage was undertaken between the Victorian Cervical Cytology Registry and National HPV Vaccination Program Register to determine quadrivalent HPV vaccination status and incidence of cervical pathology among vaccine eligible women (aged 26 years or younger in 2007) screened in Victoria, Australia between April 2007 and December 2011. Proportional hazards regression was used to estimate hazard ratios (HR) adjusted for age, socio..

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Grants

Funding Acknowledgements

We thank Genevieve Chappell, Cathryn May, Karen Winch and the information technology team at the Victorian Cytology Service (VCS Inc) for assisting with data extraction and testing, and staff at the Data Linkage Unit at the AIHW for conducting the data linkage. The VCCR is fully funded by the Victorian Department of Health and operated by the VCS. The NHVPR is owned by the Australian Government Department of Health and operated by the VCS.