Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats

J Calvez; C De Ávila; LO Matte; G Guèvremont; AL Gundlach; E Timofeeva

Journal article

Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats

J Calvez, C De Ávila, LO Matte, G Guèvremont, AL Gundlach, E Timofeeva

Neuropharmacology | Published : 2016

DOI: 10.1016/j.neuropharm.2015.11.014

Abstract

Binge eating is frequently stimulated by stress. The neuropeptide relaxin-3 (RLN3) and its native receptor RXFP3 are implicated in stress and appetitive behaviors. We investigated the dynamics of the central RLN3/RXFP3 system in a newly established model of stress-induced binge eating. Female Sprague-Dawley rats were subjected to unpredictable intermittent 1-h access to 10% sucrose. When sucrose intake stabilized, rats were assessed for consistency of higher or lower sucrose intake in response to three unpredictable episodes of foot-shock stress; and assigned as binge-like eating prone (BEP) or binge-like eating resistant (BER). BEP rats displayed elevated consumption of sucrose under non-st..

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University of Melbourne Researchers

Andrew Gundlach Author

Grants

Funding Acknowledgements

This research was financially supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and Canadian Institutes of Health Research (CIHR).