Role of relaxin-3/RXFP3 system in stress-induced binge-like eating in female rats
Juliane Calvez, Camila de Avila, Louis-Olivier Matte, Genevieve Guevremont, Andrew L Gundlach, Elena Timofeeva
Neuropharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Binge eating is frequently stimulated by stress. The neuropeptide relaxin-3 (RLN3) and its native receptor RXFP3 are implicated in stress and appetitive behaviors. We investigated the dynamics of the central RLN3/RXFP3 system in a newly established model of stress-induced binge eating. Female Sprague-Dawley rats were subjected to unpredictable intermittent 1-h access to 10% sucrose. When sucrose intake stabilized, rats were assessed for consistency of higher or lower sucrose intake in response to three unpredictable episodes of foot-shock stress; and assigned as binge-like eating prone (BEP) or binge-like eating resistant (BER). BEP rats displayed elevated consumption of sucrose under non-st..View full abstract
This research was financially supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and Canadian Institutes of Health Research (CIHR).