Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

D Scott; T Trbojevic; E Skinner; RA Clark; P Levinger; TP Haines; KM Sanders; PR Ebeling

Journal article

Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

D Scott, T Trbojevic, E Skinner, RA Clark, P Levinger, TP Haines, KM Sanders, PR Ebeling

Journal of Musculoskeletal Neuronal Interactions | Published : 2015

Abstract

Objectives: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. Methods: 48 community-dwelling older adults aged ≥65 years (mean 71.6±4.8 years; 52% women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66% tibia), to assess calf IMAT cross-sectional area ([CSA]; cm2) and muscle density (mg/cm3; higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; ..

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University of Melbourne Researchers

Pazit Levinger Author

Kerrie Sanders Author

Grants

Funding Acknowledgements

The researchers gratefully acknowledge the assistance of Catherine Shore-Lorenti, Andrew Le-Tang, Andrian Sutanto, Denny Brail, Hannah Ware, and staff of the Western Health Physiotherapy Department. This work was supported by an Australian Institute for Musculoskeletal Science Research Seed Funding Grant. Ross Clark is supported by a National Health and Medical Research Council RD Wright Biomedical Fellowship.