Journal article

pKa values of aqua ligands of platinum(II) anticancer complexes: [1H, 15N] and 195Pt NMR studies of cis- and trans-[PtCl2 (NH3)(cyclohexylamine)]

SJ Barton, KJ Barnham, A Habtemariam, RE Sue, PJ Sadler

Inorganica Chimica Acta | Published : 1998


Syntheses and NMR studies are reported of two 15N-labelled Pt(II) complexes of anticancer interest: cis-[PtCl2(15NH3)(c-C6H 1115NH2)], a metabolite of the orally-active Pt(IV) complex cis,trans,cis-[PtCl2(acetate)2(c-C6H 11NH2)(NH3)], and trans-[PtCl2(15NH3)(c-C6H 1115NH2)], a reduction product of the active Pt(IV) complex trans,trans,trans-[PtCl2(OH)2(c-C6H 11NH2)]. For cis-[PtCl2(15NH3)(c-C6H 1115NH2)], hydrolysis was faster for the chloride ligand trans to cyclohexylamine, and the pKa values determined by [1H, 15N] NMR spectroscopy for the two cis monoaqua isomers were the same (6.73). The trans monoaqua complex was a stronger acid with pKa of 5.4 (determined by 195Pt NMR). For the cis di..

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