Journal article

Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides

KJ Barnham, PJ Sadler, SJ Berners‐Price, TA Frenkiel, U Frey

Angewandte Chemie International Edition | Published : 1995

Abstract

1 15 H, N correlated NMR spectroscopy has proven to be a suitable method to investigate the reaction of the anticancer drug cisplatin cis‐[PtCl (NH ) ] (1) with DNA. All the intermediates in reactions of 1 with complementary model oligonucleotides can be detected with this method; one of these intermediates is shown. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany 2 3 2

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