Journal article
Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides
KJ Barnham, PJ Sadler, SJ Berners‐Price, TA Frenkiel, U Frey
Angewandte Chemie International Edition in English | Published : 1995
Abstract
1H, 15N correlated NMR spectroscopy has proven to be a suitable method to investigate the reaction of the anticancer drug cisplatin cis‐[PtCl2(NH3)2] (1) with DNA. All the intermediates in reactions of 1 with complementary model oligonucleotides can be detected with this method; one of these intermediates is shown. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany