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Clinical effects of polymyxin B-immobilized fiber column in septic patients

Dinna N Cruz, Rinaldo Bellomo, Claudio Ronco, C Ronco (ed.), R Bellomo (ed.), JA Kellum (ed.)

Contributions to Nephrology | KARGER | Published : 2007

Abstract

Endotoxin is one of the principal biological substances that cause gram-negative septic shock. Lack of clinical success with antiendotoxin or anticytokine therapy has shifted interest to extracorporeal therapies to reduce circulating levels of the mediators of sepsis. Direct hemoperfusion with polymyxin-B-immobilized fiber (PMX-F) is a promising treatment of gram-negative sepsis in critically ill patients. Because of the high affinity of polymyxin B for endotoxin, the rationale underlying extracorporeal therapy would be to remove circulating endotoxin by adsorption, thus preventing progression of the biological cascade of sepsis. In a systematic review of 28 studies (pooled sample size 1,390..

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University of Melbourne Researchers