Journal article

A pilot study of high-adsorption hemofiltration in human septic shock

M Haase, W Silvester, S Uchino, D Goldsmith, P Davenport, P Tipping, N Boyce, R Bellomo

The International Journal of Artificial Organs | SAGE PUBLICATIONS LTD | Published : 2007


BACKGROUND: To compare the hemodynamic and biological effects of high-adsorption continuous veno-venous hemofiltration (CVVH) with standard CVVH in septic shock. METHODS: In a randomized cross-over clinical trial twelve patients with septic shock and multiple organ failure were enrolled at a tertiary intensive care unit. Patients were allocated to either 9 hours of high-adsorption hemofiltration (CVVH with 3 hourly filter change using AN69 hemofilters - 3FCVVH) or 9 hours of standard hemofiltration (CVVH without filter change - 1F-CVVH). RESULTS: Changes in hemodynamic variables, dose of noradrenaline required to maintain a mean arterial pressure greater than 75 mmHg and plasma concentration..

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University of Melbourne Researchers