Economics of dialysis dependence following renal replacement therapy for critically ill acute kidney injury patients
Olivier Ethgen, Antoine G Schneider, Sean M Bagshaw, Rinaldo Bellomo, John A Kellum
Nephrology Dialysis Transplantation | OXFORD UNIV PRESS | Published : 2015
BACKGROUND: The obective of this study was to perform a cost-effectiveness analysis comparing intermittent with continuous renal replacement therapy (IRRT versus CRRT) as initial therapy for acute kidney injury (AKI) in the intensive care unit (ICU). METHODS: Assuming some patients would potentially be eligible for either modality, we modeled life year gained, the quality-adjusted life years (QALYs) and healthcare costs for a cohort of 1000 IRRT patients and a cohort of 1000 CRRT patients. We used a 1-year, 5-year and a lifetime horizon. A Markov model with two health states for AKI survivors was designed: dialysis dependence and dialysis independence. We applied Weibull regression from publ..View full abstract
This study was supported by a grant from Gambro. Dr. Bagshaw is supported by a 'Canada Research Chair' in Critical Care Nephrology and Clinical Investigator Award from Alberta Innovates-Health Solutions.