Journal article

Interpreting the mechanisms of continuous renal replacement therapy in sepsis: The peak concentration hypothesis

C Ronco, C Tetta, F Mariano, ML Wratten, M Bonello, V Bordoni, X Cardona, P Inguaggiato, L Pilotto, V d'Intini, R Bellomo

Artificial Organs | WILEY | Published : 2003

Abstract

Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), which is the most frequent cause of death in intensive care unit patients. Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome. In intensive care medicine, blocking any one mediator has not led to a measurable outcome improvement in patients with sepsis. CRRT is a continuously acting therapy, which removes in a nonselective way pro- and anti-inflammatory mediators; "the peak concentration hypothesis" is the concept of cutting peaks of soluble mediators through continuous hemofiltration. Furthermore, th..

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University of Melbourne Researchers