Journal article

Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial

Gordon S Doig, Fiona Simpson, Philippa T Heighes, Rinaldo Bellomo, Douglas Chesher, Ian D Caterson, Michael C Reade, Peter WJ Harrigan

The Lancet Respiratory Medicine | ELSEVIER SCI LTD | Published : 2015


BACKGROUND: Equipoise exists regarding the benefits of restricting caloric intake during electrolyte replacement for refeeding syndrome, with half of intensive care specialists choosing to continue normal caloric intake. We aimed to assess whether energy restriction affects the duration of critical illness, and other measures of morbidity, compared with standard care. METHODS: We did a randomised, multicentre, single-blind clinical trial in 13 hospital intensive care units (ICUs) in Australia (11 sites) and New Zealand (two sites). Adult critically ill patients who developed refeeding syndrome within 72 h of commencing nutritional support in the ICU were enrolled and allocated to receive con..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This project was endorsed by the Australasian Society for Parenteral and Enteral Nutrition and was supported by a peer-reviewed academic grant from the National Health and Medical Research Council of Australia (project grant 632615).