Fluid Bolus Therapy-Based Resuscitation for Severe Sepsis in Hospitalized Children: A Systematic Review
Ben Gelbart, Neil J Glassford, Rinaldo Bellomo
PEDIATRIC CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
OBJECTIVES: To review systematically data from randomized and nonrandomized studies of fluid bolus therapy in hospitalized children with septic shock. DATA SOURCES: Medline, EMBASE, and Cochrane Central Register of Controlled Trials. STUDY SELECTION: We searched for randomized controlled studies of fluid bolus therapy in children with severe sepsis. We identified retrospective, prospective, and observational studies. We excluded studies of severe sepsis/septic shock due to a specific microbiological etiology, neonatal studies, and studies where advanced supportive therapies were unavailable. DATA EXTRACTION: Two authors screened articles for inclusion. DATA SYNTHESIS: We identified and analy..View full abstract
Dr. Gelbart is employed by RCH PICU. Dr. Glassford disclosed other support from the Avant Doctors-In-Training Research Scholarship (Competitive entry scholarship programme to fund higher degree student salaries). Dr. Bellomo disclosed that he does not have any potential conflicts of interest.