Fluid bolus therapy-based resuscitation for severe sepsis in hospitalized children: A systematic review

Abstract

Objectives: To review systematically data from randomized and nonrandomized studies of fluid bolus therapy in hospitalized children with septic shock. Data Sources: Medline, EMBASE, and Cochrane Central Register of Controlled Trials. Study Selection: We searched for randomized controlled studies of fluid bolus therapy in children with severe sepsis. We identified retrospective, prospective, and observational studies. We excluded studies of severe sepsis/septic shock due to a specific microbiological etiology, neonatal studies, and studies where advanced supportive therapies were unavailable. Data Extraction: Two authors screened articles for inclusion. Data Synthesis: We identified and analy..