Journal article

Are all fluids bad for the kidney?

Johan Martensson, Rinaldo Bellomo

Current Opinion in Critical Care | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

PURPOSE OF REVIEW: To describe the harmful effects of intravenous fluids on kidney structure and function and summarize recent comparisons between different fluids and their effect on kidney outcome. RECENT FINDINGS: Administration of intravenous fluids may contribute to the development and sustention of acute kidney injury. In excess, fluids cause kidney interstitial edema and venous congestion, which prevents renal blood flow and glomerular filtration rate. In contrast to balanced crystalloids, chloride-rich solutions impair renal blood flow via autoregulatory mechanisms. Synthetic colloids, such as hydroxyethyl starches, gelatins, and dextrans are potentially nephrotoxic because they can ..

View full abstract

University of Melbourne Researchers