Journal article

Cardiovascular effects of the nitric oxide synthase inhibitor N-G-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: Results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002)

D Watson, R Grover, A Anzueto, J Lorente, M Smithies, R Bellomo, K Guntupalli, S Grossman, J Donaldson, JR Le Gall

Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2004


OBJECTIVE: To assess the hemodynamic effects of the nitric oxide synthase inhibitor 546C88 in patients with septic shock, although this was not a stated aim of the protocol. The predefined primary efficacy objective of the protocol was resolution of shock determined at the end of a 72-hr treatment period. DESIGN: Multicentered, randomized, placebo-controlled, safety and efficacy study. SETTING: Forty-eight intensive care units in Europe, North America, and Australia. PATIENTS: A total of 312 patients with septic shock diagnosed within 24 hr before randomization. INTERVENTIONS: Patients were randomly allocated to receive either 546C88 or placebo (5% dextrose) by intravenous infusion for up to..

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University of Melbourne Researchers