Journal article

Association between early peak temperature and mortality in neutropenic sepsis

Robert Weinkove, Michael Bailey, Rinaldo Bellomo, Manoj K Saxena, Constantine S Tam, David V Pilcher, Richard Beasley, Paul J Young

Annals of Hematology | SPRINGER | Published : 2015


Fever is often the first sign of neutropenic infection, but its prognostic impact has not been established. We aimed to determine whether early peak temperature is associated with mortality in patients with neutropenic sepsis admitted to intensive care units (ICUs). We used a database of admissions to 157 ICUs in Australia and New Zealand between 2005 and 2013 to seek an association between peak temperature within the first 24 h in ICU and in-hospital mortality in neutropenic and non-neutropenic sepsis. Odds ratios for in-hospital death were calculated for four temperature bands, adjusting for illness severity. Two patient cohorts were identified: neutropenic sepsis (N = 4027) and non-neutro..

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Awarded by Health Research Council of New Zealand

Funding Acknowledgements

We wish to thank the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Management Committee for reviewing the study protocol. This work was supported by the Health Research Council of New Zealand (grant number 13/699 to RW).