Journal article

HyperOxic Therapy OR NormOxic Therapy after out-of-hospital cardiac arrest (HOT OR NOT): A randomised controlled feasibility trial

Paul Young, Mark Bailey, Rinaldo Bellomo, Stephen Bernard, Bridget Dicker, Ross Freebairn, Seton Henderson, Diane Mackle, Colin McArthur, Shay McGuinness, Tony Smith, Andrew Swain, Mark Weatherall, Richard Beasley

Resuscitation | ELSEVIER IRELAND LTD | Published : 2014


AIMS: To investigate the feasibility of delivering titrated oxygen therapy to adults with return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrest (OHCA) caused by ventricular fibrillation (VF) or ventricular tachycardia (VT). METHODS: We used a multicentre, randomised, single blind, parallel groups design to compare titrated and standard oxygen therapy in adults resuscitated from VF/VT OHCA. The intervention commenced in the community following ROSC and was maintained in the emergency department and the Intensive Care Unit. The primary end point was the median oxygen saturation by pulse oximetry (SpO2) in the pre-hospital period. RESULTS: 159 OHCA patients were scre..

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University of Melbourne Researchers