Journal article

Renal replacement therapy with high-cutoff hemofilters: Impact of convection and diffusion on cytokine clearances and protein status

S Morgera, T Slowinski, C Melzer, V Sobottke, O Vargas-Hein, T Volk, H Zuckermann-Becker, B Wegner, JM Muller, G Baumann, WJ Kox, R Bellomo, HH Neumayer

American Journal of Kidney Diseases | W B SAUNDERS CO-ELSEVIER INC | Published : 2004

Abstract

BACKGROUND: High-cutoff hemofilters are characterized by an increased effective pore size designed to facilitate the elimination of inflammatory mediators in sepsis. This study compares diffusive versus convective high-cutoff renal replacement therapy (RRT) in terms of cytokine clearance rates and effects on plasma protein levels. METHODS: Twenty-four patients with sepsis-induced acute renal failure were studied. A polyflux hemofilter with a cutoff point of approximately 60 kd was used for RRT. Patients were randomly allocated to either continuous venovenous hemofiltration (CVVH) with an ultrafiltration rate of 1 L/h (group 1) or 2.5 L/h (group 2) or continuous venovenous hemodialysis (CVVHD..

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University of Melbourne Researchers