Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study
Satoshi Suzuki, Glenn M Eastwood, Michael Bailey, David Gattas, Peter Kruger, Manoj Saxena, John D Santamaria, Rinaldo Bellomo
CRITICAL CARE | BIOMED CENTRAL LTD | Published : 2015
INTRODUCTION: In this study, we aimed to examine the association between paracetamol administration in the intensive care unit (ICU) and mortality in critically ill patients. METHODS: We conducted a multicenter retrospective observational study in four ICUs. We obtained information on paracetamol use, body temperature, demographic, clinical and outcome data from each hospital's clinical information system and admissions and discharges database. We performed statistical analysis to assess the association between paracetamol administration and hospital mortality. RESULTS: We studied 15,818 patients with 691,348 temperature measurements at 4 ICUs. Of these patients, 10,046 (64%) received at lea..View full abstract
We thank Dr Paul Young for his critical advice in the redaction of the final manuscript. We thank the following ethics committees for their input: Austin Hospital Human Research Ethics Committee (Melbourne), Princess Alexandra Hospital Human Research Ethics Committee (Brisbane), Royal Prince Alfred Hospital Human Research Ethics Committee (Sydney), St George Hospital (Sydney) and St Vincent's Hospital Human Research Ethics Committee (Melbourne). This study was funded by the Austin Hospital Intensive Care Trust Fund. The funding body had no involvement in the design, collection, analysis and interpretation of data or in the writing of the manuscript or in the decision to submit the manuscript for publication.