Journal article

Design and challenges of the Randomized Evaluation of Normal versus augmented level replacement therapy (RENAL) trial: High-dose versus standard-dose hemofiltration in acute renal failure

Rinaldo Bellomo, Alan Cass, Louise Cole, Simon Finfer, Martin Gallagher, Donna Goldsmith, John Myburgh, Robyn Norton, Carlos Scheinkestel

Blood Purification | KARGER | Published : 2008


BACKGROUND/AIMS: The optimal dose of renal replacement therapy (RRT) in acute renal failure (ARF) is uncertain. METHODS: The Randomized Evaluation of Normal versus Augmented Level Replacement Therapy Trial tests the hypothesis that higher dose continuous veno-venous hemodiafiltration (CVVHDF) at an effluent rate of 40 ml/kg/h will increase survival compared to CVVHDF at 25 ml/kg/h of effluent dose. RESULTS: This trial is currently randomizing critically ill patients in 35 intensive care units in Australia and New Zealand with a planned sample size of 1,500 patients. This trial will be the largest trial ever conducted on acute blood purification in critically ill patients. CONCLUSION: A trial..

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