Journal article
A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators
DC Angus, AE Barnato, D Bell, R Bellomo, CR Chong, TJ Coats, A Davies, A Delaney, DA Harrison, A Holdgate, B Howe, DT Huang, T Iwashyna, JA Kellum, SL Peake, F Pike, MC Reade, KM Rowan, M Singer, SAR Webb Show all
Intensive Care Medicine | Published : 2015
Abstract
Purpose: To determine whether early goal-directed therapy (EGDT) reduces mortality compared with other resuscitation strategies for patients presenting to the emergency department (ED) with septic shock. Methods: Using a search strategy of PubMed, EmBase and CENTRAL, we selected all relevant randomised clinical trials published from January 2000 to January 2015. We translated non-English papers and contacted authors as necessary. Our primary analysis generated a pooled odds ratio (OR) from a fixed-effect model. Sensitivity analyses explored the effect of including non-ED studies, adjusting for study quality, and conducting a random-effects model. Secondary outcomes included organ support and..
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