Journal article
Urinary Neutrophil Gelatinase-Associated Lipocalin as Predictor of Short- or Long-Term Outcomes in Cardiac Surgery Patients
M Garcia-Alvarez, NJ Glassford, AJ Betbese, J Ordoñez, V Baños, M Argilaga, A Martínez, S Suzuki, AG Schneider, GM Eastwood, M Victoria Moral, R Bellomo
Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2015
Abstract
Objectives To determine the ability of urinary neutrophil gelatinase-associated lipocalin (uNGAL) to predict cardiac surgery-associated acute kidney injury (CSA-AKI), continuous renal replacement therapy (CRRT), mortality, and a composite outcome of major adverse kidney events at 365 days (MAKE365), and to investigate the influence of cardiopulmonary bypass (CPB) on NGAL release. Design A prospective observational study. Setting A single-center university hospital. Participants A cohort of 288 adult cardiac surgery patients. Interventions uNGAL was measured at baseline, immediately after surgery, and on days 1 and 2 postoperatively. The authors used the recent Kidney Disease Improving Global..
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Funding Acknowledgements
This project was supported in part by a grant from Abbot Diagnostics. They did not have access to the results before publication. The authors thank Abbot Diagnostics for supplying NGAL measurements kits. Dr. Garcia-Alvarez holds a predoctoral fellowship grant (BAE) from The Cabs III Institute of Health (Department of Economy and Competitiveness, Kingdom of Spain). Dr. Glassford is supported by the Monash International Graduate Research Scholarship (Monash University, Melbourne, Australia).