The acid-base effects of continuous hemofiltration with lactate or bicarbonate buffered replacement fluids

Abstract

OBJECTIVE: To evaluate, quantify and compare the effects of continuous veno-venous hemofiltration (CVVH) with lactate or bicarbonate-buffered replacement fluids on acid-base balance. DESIGN: Randomized double crossover study. SETTING: Intensive Care Unit of Tertiary Medical Center. PARTICIPANTS: Eight patients with severe acute renal failure. INTERVENTIONS: Random allocation to either 2 hours of isovolemic lactate-buffered (treatment A) CVVH or 2 hours of bicarbonate-buffered (treatment B) CVVH with cross over and with same procedure repeated the following day (double cross over). MEASUREMENTS AND RESULTS: Timed collections of arterial blood and ultrafiltrate (UF), measurement of blood and U..