Journal article

A pilot study of coupled plasma filtration with adsorption in septic shock

C Ronco, A Brendolan, G Lonnemann, R Bellomo, P Piccinni, A Digito, M Dan, M Irone, G La Greca, P Inguaggiato, U Maggiore, C De Nitti, ML Wratten, Z Ricci, C Tetta

Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2002


OBJECTIVE: To test the hypothesis that nonselective plasma adsorption by a hydrophobic resin (coupled plasmafiltration and adsorption) could improve hemodynamics and restore leukocyte responsiveness in patients with septic shock. DESIGN: Prospective, pilot, crossover clinical trial. SETTING: General intensive care unit in a teaching hospital. SUBJECTS: Ten patients with hyperdynamic septic shock. INTERVENTIONS: Patients were randomly allocated to 10 hrs of either coupled plasma filtration adsorption plus hemodialysis (treatment A) or continuous venovenous hemodiafiltration (treatment B) in random order. We measured the change in mean arterial pressure, norepinephrine requirements, and leukoc..

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University of Melbourne Researchers