Journal article
A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics
DM Roberts, X Liu, JA Roberts, P Nair, L Cole, MS Roberts, J Lipman, R Bellomo
Critical care (London, England) | Published : 2015
Open access
Abstract
INTRODUCTION: Continuous renal replacement therapy (CRRT) may alter antibiotic pharmacokinetics and increase the risk of incorrect dosing. In a nested cohort within a large randomized controlled trial, we assessed the effect of higher (40 mL/kg per hour) and lower (25 mL/kg per hour) intensity CRRT on antibiotic pharmacokinetics. METHODS: We collected serial blood samples to measure ciprofloxacin, meropenem, piperacillin-tazobactam, and vancomycin levels. We calculated extracorporeal clearance (CL), systemic CL, and volume of distribution (Vd) by non-linear mixed-effects modelling. We assessed the influence of CRRT intensity and other patient factors on antibiotic pharmacokinetics. RESULTS: ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank the research nurses in the participating institutions for recruitment and collection of samples. Financial support was provided by grants from the National Health and Medical Research Council of Australia (352550) and the Health Research Council of New Zealand (06-357). JAR is funded by a Career Development Fellowship (APP1048652) and MSR by a Senior Principal Research Fellowship (APP1002611) from the National Health and Medical Research Council of Australia. The funding organizations had no role in the design of this substudy, analysis, or decision to publish. Written informed consent was obtained from the patient or their responsible surrogate for publication in this article. The consent form is held by the authors and is available for review by the Editor-in-Chief.