The relationship between hypophosphataemia and outcomes during low-intensity and high-intensity continuous renal replacement therapy
Rinaldo Bellomo, Alan Cass, Louise Cole, Simon Finfer, Martin Gallagher, Inbyung Kim, Joanne Lee, Serigne Lo, Colin McArthur, Shay McGuiness, Robyn Norton, John Myburgh, Carlos Scheinkestel
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | AUSTRALASIAN MED PUBL CO LTD | Published : 2014
AIM: To identify risk factors for development of hypophosphataemia in patients treated with two different intensities of continuous renal replacement therapy (CRRT) and to assess the independent association of hypophosphataemia with major clinical outcomes. MATERIALS AND METHODS: We performed secondary analysis of data collected from 1441 patients during a large, multicentre randomised controlled trial of CRRT intensity. We allocated patients to two different intensities of CRRT (25mL/kg/hour vs 40 mL/kg/hour of effluent generation) and obtained daily measurement of serum phosphate levels. RESULTS: We obtained 14 115 phosphate measurements and identified 462 patients (32.1%) with hypophospha..View full abstract
Awarded by NHMRC
Awarded by Health Research Council of New Zealand
Alan Cass was supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship, and John Myburgh is supported by an NHMRC Practitioner Fellowship. Our study was funded by the NHMRC (grant 352550) and the Health Research Council of New Zealand (grant 06-357). We thank Gambro for discounted Haemosol dialysate and replacement fluids, and the nurses in our ICUs, our medical colleagues and our patients and their families for their support.