Extracorporeal treatments in sepsis: are there new perspectives?
C Tetta, V D'Intini, R Bellomo, M Bonello, V Bordoni, Z Ricci, C Ronco
Clinical Nephrology | DUSTRI-VERLAG DR KARL FEISTLE | Published : 2003
Sepsis continues to provide a major challenge to clinicians. Despite vast advancements achieved in the understanding of its pathways and mechanisms, the incidence of sepsis is increasing and the mortality and morbidity rates remain high, generating a considerable burden to health budgets worldwide. Unfortunately, no definitive therapy yet exists that can successfully treat sepsis and its complications. At variance with targeting single mediators, therapeutic intervention aimed at the non-selective removal of pro- and anti-inflammatory mediators seems a rational concept and a possible key to successful extra-corporeal therapies. A further advantage may lie in the continuous nature of such the..View full abstract