Solute mass balance during isovolaemic high volume haemofiltration

Abstract

OBJECTIVE: To evaluate the effect of changing the amount of pre-dilution replacement fluid on the sieving coefficient (SC) and mass transfer of small solutes during isovolaemic high-volume haemofiltration (HVHF). DESIGN AND SETTING: Prospective interventional study in the intensive care unit of a tertiary university hospital. PATIENTS: Eight patients with septic shock. INTERVENTIONS: Isovolaemic HVHF (6 l/h of replacement fluid) was performed. The proportion of replacement fluid delivered in pre-filter was altered to progressively decrease it from 6 to 0 l/h. Samples were simultaneously taken from the "pre-filter", "post-filter" and ultrafiltrate (UF) sampling ports. MEASUREMENTS AND RESULTS..