Journal article

Neutrophil gelatinase-associated lipocalin

Michael Haase, Rinaldo Bellomo, Anja Haase-Fielitz

Current Opinion in Critical Care | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

Abstract

PURPOSE OF REVIEW: Acute kidney injury (AKI) is a major clinical problem in hospitalized patients. Effective treatment and early diagnosis of this syndrome are not currently available. This review focuses on recent studies examining the biological characteristics and the diagnostic and prognostic value of a novel biomarker--neutrophil gelatinase-associated lipocalin (NGAL)--in the two major patient populations at risk for AKI. RECENT FINDINGS: NGAL is one of the most intensively investigated novel renal biomarkers with promising data from animal experiments and clinical studies comprising more than 3500 cardiac surgery or critically ill patients. NGAL was discovered using unbiased transcript..

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University of Melbourne Researchers