Protective effect of urate oxidase on uric acid induced-monocyte apoptosis.
Valeria Bordoni, Massimo De Cal, Mario Rassu, Stefania Cazzavillan, Chiara Segala, Monica Bonello, Rattanarat Ranishta, Emilios Andrikos, Asuman Yavuz, Gabriella Salvatori, Elisabetta Galloni, Irene Bolgan, Rinaldo Bellomo, Nathan Levin, Claudio Ronco
Current Drug Discovery Technologies | Published : 2005
Uremic patients have a higher risk of infection and malignancy than normal subjects. Previous studies have deomonstrated that monocytes isolated from uremic patients display an increased apoptosis rate compared to normal subjects; furthermore uremic plasma can increase apoptosis rates on U937, a human monocytic cell line. In several pathological conditions, precipitation of uric acid crystals can lead to renal insufficiency or acute renal failure by different mechanisms. In recent studies uric acid has been shown to induce inflammatory response from monocytes and it has been suggested to be involved in cell dysfunction. Rasburicase is a new recombinant urate oxidase developed to prevent and ..View full abstract