Journal article

The role of α-receptor manipulation in the prevention of renal dysfunction

C French, R Bellomo

Current Opinion in Critical Care | Published : 1997


There has been recent interest in the role of α-adrenoreceptor manipulation and the prevention of renal dysfunction. α2-Agonists have been used in the prevention of renal dysfunction after extracorporeal circulation. In the setting of sepsis and hypotension, α1-agonists have also been shown to be beneficial to renal function. Accordingly, we review the renal effects of α2-agonists as studied in animal models and present currently available evidence from controlled and uncontrolled human studies. Although the pathophysiology of the interaction between α-adrenoreceptor manipulation and renal function is complex, the balance of evidence suggests that central α-receptor agonists may be useful in..

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